Retin-A (Tretinoin, Avita, Renova) is a derivative of Vitamin A and is the treatment of choice for comedonal acne, or whiteheads and blackheads. It works by increasing skin cell turnover promoting the extrusion of the plugged material in the follicle. It also prevents the formation of new comedones. Tretinoin is also the only topical medication that has been proven to improve wrinkles.
The effect of increased skin cell turnover can be irritation and flaking. For this reason, many people stop using Retin-A after a couple of days to weeks, then think that it didn't work. It is important to realize that Retin-A is very effective for whiteheads and blackheads, but it may take 6-9 weeks to see a noticeable difference. It takes at least 6 months to see a noticeable difference in wrinkles. The best benefit is seen if Retin-A is used for at least a year.
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